A general method for the enantioselective synthesis of pantolactone derivatives.
نویسندگان
چکیده
An efficient enantioselective synthesis of beta,beta-dialkyl-gamma-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)](Cl)(2)(+), R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in high enantiomeric excesses. [reaction: see text]
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عنوان ژورنال:
- Organic letters
دوره 4 20 شماره
صفحات -
تاریخ انتشار 2002